Suppression specifically of the 85kD subunit in early murine embryoid body development results in a transient cell-cell adhesion deficiency, mediated by transient downregulation of the adhesion molecule integrin-beta1 (ITGB1).

Clinical significance

Mutations in PIK3R1 are implicated in cases of breast cancer.

Mutations in PIK3R1 are associated to SHORT syndrome.

Interactions

PIK3R1 has been shown to interact

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