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solution-phase techniques, although these have been replaced in most research and development settings by solid phase methods (see below). Solution phase synthesis retains its usefulness in production of small peptides for industrial purposes.

Chemical peptide synthesis facilitates the production of peptides that are difficult to express in bacteria, the incorporation of unnatural amino acids, peptide/protein backbone modification, and the synthesis of peptides containing D-amino acids.

Solid phase peptide synthesis

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