business Moses Taylor & Co. as a clerk, becoming a partner in 1842. Moses Taylor & Co. specialized in the importation and sale of sugar, focusing on the Cuban trade. Pyne managed the sugar business while Taylor expanded the company into finance, iron, coal and railroads.

After the death of his father-in-law in 1882, Pyne became president of National City Bank, which was founded by Taylor in 1865, serving in that role until 1891 when he was succeeded