strand or strands through the break and repairing the break; the broken ends of the DNA are covalently linked to topoisomerase. SPO11 is similarly attached to the DNA when it forms double-strand breaks during meiosis.

Meiotic recombination

SPO11 is considered to play a predominant role in initiating meiotic recombination. However, recombination may also occur by alternative SPO11-independent mechanisms that can be studied experimentally using spo11 mutants.

In the budding yeast Saccharomyces

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