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Quaternization of triphenylphosphine with secondary halides is typically inefficient. For this reason, Wittig reagents are rarely used to prepare tetrasubstituted alkenes.

Bases for deprotonation of phosphonium salts

The alkylphosphonium salt is deprotonated with a strong base such as ''n''-butyllithium:
:[Ph₃P⁺CH₂R]X^- + C₄H₉Li -> Ph₃P=CHR + LiX + C₄H₁₀Besides n-butyllithium (ⁿBuLi),

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