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for proper amino acid utilization and energy homeostasis in humans.

Catalysis of isovaleryl-CoA dehydrogenase

The enzyme, isovaleryl-CoA dehydrogenase (IVD), part of the family of acyl-CoA dehydogenases (ACDs), is activated through the substrate binding of isovaleryl-CoA, within the hydrophobic pocket tailored to accommodate its branched alkyl chain. Upon substrate binding, conformational changes position

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