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noted that powder made from dried and ground bioluminescent creatures glowed when water was added. The first experimental studies of luciferin-luciferase systems were performed by the French scientist Raphael Dubois. Utilizing glow-worms and fireflies in 1885, he discovered that a substance is consumed during the light-producing reaction. Dubois eventually extracted two compounds responsible for the glow; the first component, resistant to heat, was named luciferin. He called

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