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<p>chemical and biological agents, resulting in <a href="page.php?w=mutation">mutation</a>s. <a href="page.php?w=Hermann_Joseph_Muller">Hermann Muller</a> found that "high temperatures" have the ability to mutate genes in the early 1920s, and in 1927, demonstrated a causal link to mutation upon experimenting with an <a href="page.php?w=x-ray_machine">x-ray machine</a>, noting <a href="page.php?w=phylogenetic">phylogenetic</a> changes when irradiating <a href="page.php?w=Drosophila_melanogaster">fruit flies</a> with relatively <a href="page.php?w=dose_rate">high dose</a></p><p>
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