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tyrosine kinase signaling component Ret and a unit of glycosylphosphatidylinsitol (GPI)-anchored receptor (GFR?). Persephin specifically binds to GFR?4.

Persephin acts on both neurons in the CNS and PNS, but also has the ability to act as a renal ramogen.

Structure

Unlike other GDNF family of ligands, persephin only contains one RXXR cleavage site, rather than multiple, indicating that it can only make one length of functional peptide.

Therapeutics

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