group. The classification of prostaglandin E is determined by the positioning of a ketone group at the 9th carbon position and hydroxyl at the 11th carbon position, which differs from other types of prostaglandin in the human body.

Members of the prostaglandin E family are synthesized through the oxidation of polyunsaturated fatty acid substrates by cyclooxygenase (COX) enzymes. PGE₁ and PGE₂ differ in their