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nature, the word melancholy itself deriving from the Greek for 'black bile', u?????? ???? melaina kholé. Depression was attributed to excess or unnatural black bile secreted by the spleen.Cancer was also attributed to an excess of black bile concentrated in a specific area. The seasonal association of black bile was to autumn as the cold and dry characteristics of the season reflect the nature of man. Black bile was generally seen as the most detrimental of the humors and within Galenic-Hippocratic

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