by caspases and in fungi and plants, apoptosis is induced by arginine and lysine-specific caspase-like proteases called metacaspases. Homology searches revealed a close homology between caspases and the caspase-like proteins of Reticulomyxa (a unicellular organism). The phylogenetic study indicates that divergence of caspase and metacaspase sequences occurred before the divergence of eukaryotes.

Detection

Detection of executioner caspase activity frequently utilizes the tetrapeptide DEVD, which corresponds to the preferred

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