OCD has been proposed to reflect a positive feedback loop due to mutual excitation of the OFC and subcortical structures. While the OFC is usually overactive during symptom provocation tasks, cognitive tasks usually elicit hypoactivity of the OFC; This may reflect a distinction between emotional and non-emotional tasks, lateral and medial OFC, or simply just inconsistent methodologies.

Addiction

Animal models and cell-specific manipulations in relation to drug-seeking behavior implicate dysfunction of the OFC in addiction. Substance use disorders

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