428 to 431, which emphasized the disunion between the human and divine natures of Jesus. Nestorius and his doctrine were condemned at the Council of Ephesus in 431, leading to the Nestorian Schism in which churches supporting Nestorius split from the rest of Christianity.

Many followers relocated to Persia and became affiliated with the local Christian community there. This community adopted an increasingly Nestorian theology and was thereafter often known as the