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are associated with a variety of deficits related to flexible goal-directed behavior and decision-making. These deficits overlap with symptoms related to OFC lesions, and are also associated with reduced orbitofrontal grey matter, resting state hypometabolism, and blunted OFC activity during tasks involving decision-making or goal-directed behavior. In contrast to resting state and decision-related activity, cues associated with drugs evoke robust OFC activity that correlates with craving. Rodent studies

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