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growth, productivity and innovative research. At the end of the Middle Ages, about 400 years after the first European university was founded, there were 29 universities spread throughout Europe. In the 15th century, 28 new ones were created, with another 18 added between 1500 and 1625. This pace continued until by the end of the 18th century there were approximately 143 universities in Europe, with the highest concentrations in the Holy Roman Empire (34), Italian countries (26), France (25), and Spain

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