used in research settings to distinguish between the effects of testosterone caused by binding to the AR and those caused by testosterone's conversion to estradiol and subsequent binding to and activation of ERs. Although DHT cannot be aromatized, it is still transformed into metabolites with significant ER affinity and activity. These are 3?-androstanediol and 3?-androstanediol, which are predominant agonists of the ER?.

Biochemistry

Biosynthesis

DHT is synthesized irreversibly

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