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<p>4 subjects to one group and 2 to the other. This type of randomization can be combined with "<a href="page.php?w=stratified_randomization">stratified randomization</a>", for example by center in a <a href="page.php?w=multicenter_trial">multicenter trial</a>, to "ensure good balance of participant characteristics in each group." A special case of permuted-block randomization is random allocation, in which the entire sample is treated as one block. The major disadvantage of permuted-block randomization is that even if the block sizes are large</p><p>
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