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The earliest printed books and broadsheets are known as incunabula. The first printed herbal appeared in 1469, a version of Pliny's Historia Naturalis; it was published nine years before Dioscorides De Materia Medica was set in type. Important incunabula include the encyclopaedic De Proprietatibus Rerum of Franciscan friar Bartholomew Anglicus (c. 1203-1272) which, as a manuscript,

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