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:L-alanine + ?-ketoglutarate ? pyruvate + L-glutamate
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ALT (and all aminotransferases) require the coenzyme pyridoxal phosphate, which is converted into pyridoxamine in the first phase of the reaction, when an amino acid is converted into a keto acid.

Clinical significance

ALT is commonly measured clinically as part of liver function tests and is a component

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