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Fc?RIIIa is expressed on mast cells, macrophages, and natural killer cells as a transmembrane receptor, Fc?RIIIb is only expressed on neutrophils. In addition, Fc?RIIIb is the only Fc receptor anchored to the cell membrane by a glycosyl-phosphatidylinositol (GPI) linker, and also plays a significant role in triggering calcium mobilization and neutrophil degranulation. Fc?RIIIa and Fc?RIIIb together are able to activate

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