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Both CD80 and CD86 share a conserved amino acid motif that forms their ligand binding domain. CD86 consists of Ig-like extracellular domains (one variable and one constant), a transmembrane region and a short cytoplasmic domain that is longer than that of CD80. costimulatory ligands CD80 and CD86 can be found on professional antigen presenting cells such as monocytes, dendritic

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