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Carathéodory family spent 1874-75 in Constantinople, where Constantin's paternal grandfather lived, while his father Stephanos was on leave. Then in 1875 they went to Brussels when Stephanos was appointed there as Ottoman Ambassador. In Brussels, Constantin's younger sister Julia was born. The year 1879 was a tragic one for the family since Constantin's paternal grandfather died in that year, but much more tragically, Constantin's mother Despina died of pneumonia in Cannes. Constantin's

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