variety show, where he played the "extremely nervous man" in Allen's mock "Man in the Street" interviews. In 1958, Knotts made his film debut in the adapted version of No Time for Sergeants.

Knotts was cast as deputy Barney Fife on television's The Andy Griffith Show, which ran from 1960 to 1968. He reprised the character on other shows, such as The Joey Bishop Show and Return to Mayberry.