pointed to a restriction point (R-point) in G₁ where cells can enter G₀ before the R-point but are committed to mitosis after the R-point. These early studies provided evidence for the existence of a G₀ state to which access is restricted. These cells that do not divide further exit G₁ phase to enter an inactive stage called quiescent stage.

Diversity of G₀ states

Three G₀ states exist and can be categorized as

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