Today he is best known for his contribution to vegetarianism.

Cheyne was acquainted with Sir Isaac Newton and provoked Newton to publish his Quadratures and with it, his Light & Colours. Newton later offered him financial support to publish Fluxionum methodus inversa (The Inverse Method of Fluxions), but apparently he turned down the offer. Newton refused to see him any more.

Cheyne did not believe that the present state of things is "from all Eternity".

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