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Common impurities include Cu, Ni, Zn, Mn, Cr, Sb and As. Ni impurities are of particular interest because the structural similarity between Ni-doped greigite and the {{chem2 present in biological enzymes has led to suggestions that greigite or similar minerals could have acted as catalysts for the origin of life. In particular, the cubic Fe₄S₄ unit of greigite is found in the Fe₄S₄ thiocubane units of proteins of

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