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insect bites)
* Anaphylactic or anaphylactoid reactions--adjunct only

First-generation H₁-antihistamines can act on the central nervous system. As a result, they are also used for:
* Nausea, vomiting, and motion sickness
* Sedation

H₁-antihistamines can be administered topically (through the skin, nose, or eyes)

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