have all praised The Wine Bible as one of the best wine books. The Wine Bible was also featured in the Netflix series Uncorked and the Starz series Sweetbitter in Season 1 Episode 4, titled "Simone's." Her second book was Wine, Food & Friends (2006), and she was the host of a 13-episode PBS series titled Wine, Food and Friends with Karen MacNeil (in tandem with the book), for which she won an Emmy.

MacNeil was the creator of and