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However, a molecular phylogenetics study has shown that, while Pholiotina as currently defined is polyphyletic, the three clades that have been placed in Pholiotina are more closely related to other genera than to Conocybe. The two genera can be distinguished microscopically: Pholiotina contains a differentiated central zone called a mediostratum that is lacking in Conocybe. Additionally, most Pholiotina species have cystidia

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