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the sequences of genes with known functions. When several genes with similar sequences but differing functions are involved, this method alone is ineffective in determining function. A specific example is presented in the paper "Gastronomic Delights: A movable feast". Gene predictions based on sequence similarity alone had been used to predict that Helicobacter pylori can repair mismatched DNA. This prediction was based on the fact that this organism has a gene for which

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