However, Axidares was deposed by Trajan in 113 AD due to the bypass of Roman consensus regarding the appointment to the Armenian throne. According to several sources and studies, Sanatruces is linked to the anti-Roman uprising that broke out against Trajan in 117 AD, possibly serving as one of its leaders.

According to Movses Khorenatsi, during Sanatruce's childhood, King Abgar's sister, Awde, took him from Edessa