in mammals in 1960, it remains one of the least understood of all DNA polymerases. In 2016-18, TdT was discovered to demonstrate short patch DNA synthesis in an in trans template-dependent manner in addition to its more broadly known template-independent behaviour

TdT is absent in fetal liver HSCs, significantly impairing junctional diversity in B-cells during the fetal period.

Function and regulation

Generally, TdT catalyses

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