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<p><a href="page.php?w=restriction_enzyme">restriction enzyme</a>s, while the DNA to be copied is also cut with the same restriction enzyme, producing complementary <a href="page.php?w=sticky_end">sticky-ends</a>. This allows the foreign DNA to <a href="page.php?w=Nucleic_acid_hybridisation">hybridise</a> with the plasmid DNA and be sealed by DNA <a href="page.php?w=enzyme">ligase enzyme</a>, creating a genetic code not normally found in nature. Altered DNA is inserted into plasmids for replication.</p>

<p><big>In nature</big></p>
<p>A study published in</p><p>
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