moved to Schoenbrunn (near Gnadenhutten, Ohio) in 1772. In 1792, the chief of the Cayugas and approximately 20 other families rebuilt the town.

In the 19th century, the town began to prosper as it became a shipping area for logs and other items on the Susquehanna River. In 1820, the construction of the Welles Mill along Wyalusing Creek made Wyalusing a prime area