anomeric effect can also be generalized to any cyclohexyl or linear system with the general formula , where Y is a heteroatom with one or more lone pairs, and X is an electronegative atom or group. The magnitude of the anomeric effect is estimated at 4-8 kJ/mol in the case of sugars, but is different for every molecule.

In the above case, the methoxy group on the cyclohexane ring (top)