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chaperone, heat shock cognate protein of 70 kDa (hsc70) which targets the substrate to the lysosome surface. This substrate protein-chaperone complex binds to lysosome-associated membrane protein type 2A (LAMP-2A), which acts as the receptor for this pathway. LAMP-2A a single span membrane protein, is one of the three spliced variants of a single gene lamp2. The other two isoforms LAMP-2B and LAMP-2C are involved in macroautophagy and vesicular trafficking, respectively. Substrate

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