Normally a chromosome has just one centromere, but in chromosome 2 there are remnants of a second centromere in the q21.3-q22.1 region.
* The presence of vestigial telomeres. These are normally found only at the ends of a chromosome, but in chromosome 2 there are additional telomere sequences in the q13 band, far from either end of the chromosome.

The timing of the fusion has been differently estimated by different researchers.

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