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receptors of the ileum to take up B₁₂-IF complexes by endocytosis-mediated absorption before B₁₂ is finally released into circulation. Without IF, only 1% of vitamin B₁₂ is ultimately absorbed.

Serum

HC is present in blood serum where it binds 80-90% of circulating B₁₂, rendering it unavailable for cellular uptake by transcobalamin II. This is conjectured to be a circulating storage function.

Several

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