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<p>not recommended during that period. It works by inhibiting the production of <a href="page.php?w=prostaglandin">prostaglandin</a>s by decreasing the activity of the enzyme <a href="page.php?w=cyclooxygenase">cyclooxygenase</a> (COX). Ibuprofen is a weaker anti-inflammatory agent than other NSAIDs.</p>

<p>Ibuprofen was discovered in 1961 in Nottingham, UK, by <a href="page.php?w=Stewart_Adams_%28chemist%29">Stewart Adams</a> and John Nicholson while working at <a href="page.php?w=Boots_UK_Limited">Boots the Chemists</a> and initially sold as</p><p>
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