TBG is a serpin; however, it has no inhibitory function like many other members of this class of proteins.

Role in diagnosis

Thyroxine-binding globulin tests are sometimes used to find the cause of raised or lowered levels of thyroid hormone. This is done by measuring resin binding to labeled thyroid hormone, which happens only when the labeled thyroid hormone is free.

The patient's serum is mixed with the labeled thyroid hormone; next, the resin is added to the whole mixture to measure

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