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The reverse pathway is present in several organisms, including humans, and involves the transfer of the thiol group from homocysteine to cysteine via a similar mechanism. In Klebsiella pneumoniae the cystathionine ?-synthase is encoded by mtcB, while the ?-lyase is encoded by mtcC.Humans are auxotrophic for methionine, therefore it's considered to be an essential amino acid.

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