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In their paper, Andrikou & Arnone (2015) argue that to truly understand the evolution of muscle cells, the function of transcriptional regulators must be understood in the context of other external and internal interactions. Through their analysis, Andrikou & Arnone found that there were conserved orthologues of the gene regulatory network in both invertebrate bilaterians and cnidarians. They argue that having this common, general regulatory circuit allowed for a high degree of divergence from a single well-functioning

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