his service in the American Civil War, Busch began working as a salesman for the Anheuser Brewery. Busch purchased D'Oench's share of the company in 1869, and he assumed the role of company secretary from that time until the death of his father-in-law.

Adolphus Busch was the first American brewer to use pasteurization to keep beer fresh; the first to use mechanical refrigeration and refrigerated railroad cars,