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Vogelstein and his colleagues demonstrated that p53 had a much more specific activity: it bound DNA in a sequence-specific manner. They precisely defined its consensus recognition sequence and showed that virtually all p53 mutations found in tumors resulted in loss of the sequence-specific transcriptional activation properties of p53. They subsequently discovered genes that are directly activated by p53 to control cell birth and cell death. His group's more recent studies examining the entire compendium of human genes have shown that the TP53

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