are regulatory regions decorated with histone marks that are associated with both positive and negative transcriptional outcomes. Finally, we highlight the potential link between bivalency and cancer which could drive biomedical research in disease etiology and treatment.

Structure

A bivalent is the association of two replicated homologous chromosomes having exchanged DNA strand in at least one site called chiasmata. Each bivalent contains a minimum of one chiasma and rarely more than three. This limited number (much lower

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