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This generates a weak spot through which the cytoplasm flows, leading to the expansion of the bulge of membrane by increasing the surface area through tearing of the membrane from the cortex, during which time, actin levels decrease. The cytoplasmic flow is driven by hydrostatic pressure inside the cell. Before the bleb is able to expand, pressure must build enough to reach a threshold. This threshold is the amount of pressure needed to overcome the resistance of the plasma membrane

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