cells, and even activated B-cells. They can also be induced on other cell types, for example T cells. CD86 expression is more abundant compared to CD80, and upon its activation is CD86 increased faster than CD80.

At the protein level, CD86 shares 25% identity with CD80 and both are coded on human chromosome 3q13.33q21.

Role in co-stimulation, T-cell activation and inhibition

CD86 and CD80 bind as ligands to costimulatory molecule CD28 on the surface of all naïve T cells,

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