works directly through Cdx binding sites. Mutations to these binding sites have shown to ultimately prevent Hox gene expression and affect proper establishment of the body plan by preventing regulation of region-specific expression.

Research demonstrating decreases in Cdx dosage within mice has shown defects in anterior and posterior axis development. This has shown more severe vertebral defects posteriorly as Cdx dosage decreases. Along with this, it has been found that as Cdx dosage decreases, modification of Wnt signaling, and timing