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<p>to eliminate out-of-focus signal - the name "confocal" stems from this configuration. As only light produced by fluorescence very close to the <a href="page.php?w=focal_plane">focal plane</a> can be detected, the image's <a href="page.php?w=optical_resolution">optical resolution</a>, particularly in the sample depth direction, is much better than that of wide-field microscopes. However, as much of the light from sample fluorescence is blocked at the pinhole, this increased resolution is at the cost of decreased signal intensity - so long <a href="page.php?w=exposure_%28photography%29">exposure</a>s</p><p>
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